| RNase MRP | |
|---|---|
| Predicted secondary structure and sequence conservation of RNase_MRP | |
| Identifiers | |
| Symbol | RNase_MRP |
| Rfam | RF00030 |
| Other data | |
| RNA type | Gene; ribozyme |
| Domain(s) | Eukaryota |
| GO | 0006364 0000171 0000172 |
| SO | 0000385 |
RNase MRP is an enzymatically active ribonucleoprotein with two distinct roles in eukaryotes. In mitochondria it plays a direct role in the initiation of mitochondrial DNA replication. In the nucleus it is involved in precursor rRNA processing, where it cleaves the internal transcribed spacer 1 between 18S and 5.8S rRNAs. Despite distinct functions, RNase MRP has been shown to be evolutionarily related to RNase P. Like eukaryotic RNase P, RNase MRP is not catalytically active without associated protein subunits.